Taibah University College of Applied Medical Sciences Clinical Laboratory Sciences Department The Supervision of Dr Saber Eweda Assignment on “Glutathione structure function” Student Name

Taibah University

College of Applied Medical Sciences
Clinical Laboratory Sciences Department
The Supervision of Dr Saber Eweda
Assignment on “Glutathione structure function”
Student Name : Abdullah Hasan Hafiz
Number : 3900981
Section : MLT 1
Glutarthione
Glutathione is a potent, as a logical result take place in the intracellular antioxidant. Glutathione stages are remarkably decreased in the substantial nigra, of patients with early Parkinson’s disease. Glutathione has been trialed tow times every day intravenous infusion in a small open label study. 
Structure
Is tripeptide composed of three amino acid (L-cysteine, L-gltamic, L-glycin) found mostly in mammalian tissue. Behave as detoxify poison an antioxidant, and radical scavenger. Glutathione is essential for the enzymes as cofactor (glutathione peroxidase), in the synthesis of leukotrienes and uptake of amino acids. As glutathione S-transferase substrate, this substance react with many number of dangers chemical substances such as free radical, halides and epoxides to produce dangers inactive products. These reaction these reactions in the erythrocytes stop the oxidative damage toward the reduction of peroxides and methemoglobin. Glutathione take part in the maintenance and formation of disulfide bonds in proteins and also transport of amino acids through cell membranes.

Glutathione is formed and synthesized of cysteine, the most essential part of the body toxic waste disposal team. Similar to cysteine, glutathione contains the crucial thiol (-SH) group, that makes it an effective antioxidant. Nearly there is no living organism on the planet animal or plant whose cells done have glutathione. Glutathione has many roles and none of them behave alone. Work as coenzyme in many enzymatic reactions. The most essential of these redox reactions, in where the thiol grouping on the cysteine portion in the cell membranes protects against peroxidation and conjucation reactions, glutathione in the liver bounds with toxic chemicals to detoxify them. And it’s essential in RBC,s (red blood cells) and WBC,s (white blood cells) formation and across the immune system. The clinical uses of glutathione include the neutralizing of oxygen toxicity in hyperbaric oxygen therapy, reducing of toxicity of radiation and chemotherapy in cancer treatment. Glutathione take part in leukotriene synthesis and is a cofactor for enzyme glutathione peroxidase. It is also essential as a hydrophilic molecule that is inserted to lipophilic toxins and wastes in the liver during biotransformation before they become part of the bile. Glutathione take part in the detoxification of methylglyoxal, a toxin is decreased by metabolism. And this detoxification is maintained by the glyoxalase system.

Structure summary
Chemicals names Glutathione, L-glutathione, isethion, Tathion
Formation Cysteine, glutamic acid, and glycine
Molecular formula C10H17N3O6S
Molecular weight 307 g/mol

Function
Reduces the oxidative stress
the oxidative stress take place when there is no balance between the production of the free radicals and the ability of the body to fight them. High levels of oxidative stress can cause many diseases. Diabetes, cancer, and rheumatoid arthritis. So the glutathione helps tho prevent the impact of the oxidative stress.

Prevent cell damage on alcoholic fatty liver disease
Cell destruction in the liver can be reduced by glutathione.

And can support protein, enzyme, and bilibrubin stages with alcoholic fatty liver diseases.

Support insulin resistance in older individuals
They had glycine and cysteine put together to there food to increase glutathione stages, improving the resistance of insulin and fat burning.

Lower symptoms of parkinson’s disease
This disease effects central CNS (central nervous system) and known as tremors.

Improve mobility for patient with peripheral artery disease
Peripheral artery disease take place when the arteries become clogged. It most of the time occur in the lower part of the body.

Boost natural production in the body
Glutathione had sulfur molecules, that is why it help natural production in the body.
Summary
Glutathione is highly effective antioxidant formed in the cells. It is formed of three amino acids: glutamine, glycine and cysteine.

Glutathione stages in the cells can be lowered by many factors, they include poor nutrition, stress and toxins and levels also reduced due to aging. Buffing glutathione give many health benefits, including oxidative stress reduction.

References
pubchem.ncbi.nlm.nih.gov
www.healthline.com